Polynucleotides: Repair, not replace.

When people hear the word "injectable", they often think it will either add volume or relax muscles. Polynucleotides are different.

Rather than changing the shape of the face or replacing lost volume, they support the skin's own repair processes. Over time, they encourage collagen and elastin production, improve hydration and help strengthen the skin from within.

At Glow with Dr Hazel in Manchester, I often describe them as a repair treatment rather than a replacement treatment. By supporting healthier, stronger skin, they can complement other treatments and help the skin age more gracefully over time.

Polynucleotides can be particularly beneficial for:

  • Thin, crepey skin

  • Early signs of ageing

  • Under-eye skin quality

  • The neck and other delicate areas

  • Patients who want to improve their skin without adding volume

They aren't designed to create dramatic lift or tightening. Instead, the improvements are subtle and develop gradually throughout a course of treatment.

Polynucleotides work over weeks rather than days because the biological processes they stimulate take time. The aim isn't an immediate transformation, but healthier, more resilient skin with improved texture and quality.

As we age, collagen production slows, elastin weakens and the skin's ability to repair itself gradually declines. Treatments that safely stimulate these natural repair processes can help support long-term skin health, rather than simply masking visible changes.

Polynucleotides are often a good option for patients who:

  • Prefer subtle, natural-looking results

  • Understand that improvements develop gradually

  • Are happy to commit to a course of treatment

  • Want to improve skin quality rather than change their facial structure

As with any injectable treatment, a consultation is essential. At Glow with Dr Hazel in Manchester, every treatment begins with a thorough assessment to determine whether polynucleotides are appropriate, discuss the potential risks and side effects and ensure the treatment fits within your wider skin health plan.

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How We Choose Between Skin Boosters, Microneedling & Polynucleotides

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What Collagen Banking Actually Is - And Why It Works Best as a Plan